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Wild About Travel drew my attention to the demise of Uruguay-based Pluna. Airfares in southern South America are generally very expensive and award availability intra-region is often limited. I previously touted Pluna as a good option to fill in gaps on trips, and flew them several times, with the added bonus of stopovers in Montevideo, Urugauy.
For international travelers, Plunas routes to Foz do Iguaçu, the Brazilian side of Iguazú Falls, and Asunción, Paraguay will be particularly missed.
Paraguay is ill-served in flight options. Asunción (ASU) has a handful of international flights on pricey regional carriers. Travelers from the US soon can fly nonstop from Miami on American, 4 days/week beginning November 15, 2012.
Though Pluna was based in Uruguay, options there are are still reasonably plentiful without Pluna.